My first thought: Between hope and despair ... they did often find me there ... but now I take a pill for that ... and I do not care where I hang my hat! Sorry to be so silly. This is very good ... and what I really want to say is: You are a wonderful friend
Again...such vibrant textures and design and the facial expression is very expressive - almost kind of peaceful, which I find interesting when I consider your title and also the circle shape in the background. Maybe that's where peace lies - within the acceptance of both sides.
I think this is interesting because hope was the only 'good' thing found in pandora's box, but in my opinion, hope is not that great of a thing. So hope and despair to me are very similar things and can be depicted in similar ways as you have done so nicely here.